Placental expression of endoglin, placental growth factor, leptin, and hypoxia-inducible factor-1 in diabetic pregnancy and pre-eclampsia

Placental expression of endoglin, placental growth factor, leptin, and hypoxia-inducible factor-1 in diabetic pregnancy and pre-eclampsia Научная публикация

Журнал

Gynecological Endocrinology
ISSN: 0951-3590 , E-ISSN: 1473-0766

Вых. Данные

Год: 2021, Том: 37, Номер: sup1, Страницы: 35-39 Страниц : 5 DOI: 10.1080/09513590.2021.2006513

Авторы

Kapustin Roman V. ^1,2 , Kopteeva Ekaterina V. ² , Alekseenkova Elena N. ¹ , Tral Tatyana G. ^3,4 , Tolibova Gulrukhsor Kh. ^3,5 , Arzhanova Olga N. ^1,2

Организации

1	D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, Department of Obstetrics, Division of Maternal-FetalMedicine, St. Petersburg, Russia
2	Department of Obstetrics, Gynecology and Reproduction, Faculty of Medicine, St. Petersburg State University,St Petersburg, Russia
3	D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, Department of pathology, St.Petersburg, Russia
4	Saint Petersburg State Pediatric Medical University of Health Ministry of Russia, Saint Petersburg, Russia
5	I.I. Mechnikovnorth-Western state Medical University, Saint Petersburg, Russia

Objective To evaluate a level of expression of endoglin (Eng), leptin (Lep), placental growth factor (PlGF), and hypoxia-inducible factor-1alpha (HIF-1 alpha) in placenta among women with pre-eclampsia and diabetes mellitus (DM), considering the method of glycemia correction and preconception care. Materials and methods A retrospective cohort study was conducted. A total of 124 women were divided into following groups: type 1 DM (n = 40), type 2DM (n = 31), gestational DM (n = 33), pre-eclampsia without DM (PE) (n = 10) and the control group (n = 10). The histochemical study was performed by using primary monoclonal antibodies to Eng, PlGF, Lep, and HIF-1 alpha (Abcam, UK). Results The highest level of placental expression of Eng was observed in the PE group (20.34%). The same trend was also typical for T1DM (not planned) and insulin-treated groups: T2DM and GDM. An amount of cell with an PlGF expression was significantly higher in the control group (12.2%), while the lowest was observed in the pre-eclampsia group (1.18%) and T1DM (not planned) (1.26%). The placental leptin expression within each DM group was increased among the patients with unplanned pregnancy and those who received insulin therapy. We observed the lowest Lep expression in the PE group (6.3%). High level of HIF-1 alpha expression was detected in T1DM (not planned) (30.44%) and PE (29.64%) as compared to the control group (11.62%). In T2DM and GDM insulin groups, the HIF-1 alpha expression was significantly higher as compared to diet groups. Conclusion The obtained data show that DM and pre-eclampsia are associated with changes in angiogenic and metabolic placental factor expressions. The degree of changes depends on preconception care and the control of glycemia level during pregnancy.

Kapustin R.V. , Kopteeva E.V. , Alekseenkova E.N. , Tral T.G. , Tolibova G.K. , Arzhanova O.N.
Placental expression of endoglin, placental growth factor, leptin, and hypoxia-inducible factor-1 in diabetic pregnancy and pre-eclampsia
Gynecological Endocrinology. 2021. V.37. Nsup1. P.35-39. DOI: 10.1080/09513590.2021.2006513 WOS РИНЦ PMID OpenAlex

Web of science:	WOS:000733630900009
РИНЦ:	47548380
PMID (PubMed):	34937509
OpenAlex:	W4200009059

БД	Цитирований
Web of science	8
OpenAlex	8