Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia

Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia Full article

Journal

European Journal of Clinical Microbiology & Infectious Diseases
ISSN: 1435-4373 , E-ISSN: 0934-9723

Output data

Year: 2020, Volume: 39, Number: 7, Pages: 1221-1230 Pages count : 10 DOI: 10.1007/s10096-020-03831-w

Authors

Shipitsyna Elena ¹ , Khusnutdinova Tatiana ¹ , Budilovskaya Olga ¹ , Krysanova Anna ¹ , Shalepo Kira ¹ , Savicheva Alevtina ¹ , Unemo Magnus ²

Affiliations

1	Laboratory of Microbiology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia
2	WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, SE-701 82, Örebro University, Örebro, Sweden

The large majority of studies investigating associations between bacterial vaginosis (BV) and sexually transmitted infections (STIs) have been conducted among predominantly young women with high risk for STIs. Since a risky sexual behavior is a significant risk factor for both STIs and BV, this creates a bias toward an increased association between BV and STIs. This study evaluated associations between BV-associated vaginal microbiota and STIs (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, and Neisseria gonorrhoeae) in a population of women with low risk for STIs and investigated STI outcomes depending on the dominating Lactobacillus species. Repository cervicovaginal samples collected from reproductive-age women from January 2014 to February 2019 were characterized for vaginal microbiota types and the STIs using multiplex real-time PCR assays. In total, 95 STI-positive and 91 STI-negative samples were included. A significant, age-independent association between BV-associated vaginal microbiota and the presence of C. trachomatis, M. genitalium, and T. vaginalis infections was identified (age-adjusted odds ratios 2.92 [95% confidence interval (CI) 1.24–7.03], 2.88 [95% CI 1.19–7.16], and 9.75 × 107 [95% CI 13.03-∞], respectively). Normal vaginal microbiota dominated by Lactobacillus crispatus, L. gasseri, or L. jensenii was a strong protective factor against C. trachomatis and/or M. genitalium infections, whereas L. iners-dominated microbiota was not significantly associated with C. trachomatis and/or M. genitalium positivity. The results of the present study confirm that STI prevention strategies should include interventions that also reduce the incidence of BV and promote a protective vaginal microbiota in both high- and low-risk women.

Shipitsyna E. , Khusnutdinova T. , Budilovskaya O. , Krysanova A. , Shalepo K. , Savicheva A. , Unemo M.
Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia
European Journal of Clinical Microbiology & Infectious Diseases. 2020. V.39. N7. P.1221-1230. DOI: 10.1007/s10096-020-03831-w WOS Scopus РИНЦ OpenAlex

Published online:

Feb 8, 2020

Web of science:	WOS:000516056200001
Scopus:	eid_2-s2.0-85079199536
Elibrary:	43245659
OpenAlex:	W3006394881

DB	Citing
OpenAlex	37
Web of science	25