Placental microRNA expression in pregnancies complicated by superimposed pre-eclampsia on chronic hypertension

Placental microRNA expression in pregnancies complicated by superimposed pre-eclampsia on chronic hypertension Научная публикация

Журнал

Molecular Medicine Reports
ISSN: 1791-2997 , E-ISSN: 1791-3004

Вых. Данные

Год: 2016, Том: 14, Номер: 1, Страницы: 22-32 Страниц : 11 DOI: 10.3892/mmr.2016.5268

Авторы

VASHUKOVA ELENA S. ¹ , GLOTOV ANDREY S. ¹ , FEDOTOV PAVEL V. ² , EFIMOVA OLGA A. ¹ , PAKIN VLADIMIR S. ¹ , MOZGOVAYA ELENA V. ¹ , PENDINA ANNA A. ¹ , TIKHONOV ANDREI V. ¹ , KOLTSOVA ALLA S. ¹ , BARANOV VLADISLAV S. ¹

Организации

1	D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg 199034, Russian Federation
2	Computer Technologies Laboratory, ITMO University, St. Petersburg 197101, Russian Federation

Pre-eclampsia (PE) is a complication of pregnancy that affects 5-8% of women after 20 weeks of gestation. It is usually diagnosed based on the de novo onset of hypertension and proteinuria. Preexisting hypertension in women developing PE, also known as superimposed PE on chronic hypertension (SPE), leads to elevated risk of maternal and fetal mortality. PE is associated with an altered microRNA (miRNA) expression pattern in the placenta, suggesting that miRNA deregulation is involved in the pathogenesis of PE. Whether and how the miRNA expression pattern is changed in the SPE placenta remains unclear. The present study analyzed the placental miRNA expression profile in pregnancies complicated by SPE. miRNA expression profiles in SPE and normal placentas were investigated using an Ion Torrent sequencing system. Sequencing data were processed using a comprehensive analysis pipeline for deep miRNA sequencing (CAP-miRSeq). A total of 22 miRNAs were identified to be deregulated in placentas from patients with SPE. They included 16 miRNAs previously known to be associated with PE and 6 novel miRNAs. Among the 6 novel miRNAs, 4 were upregulated (miR-518a, miR-527, miR-518e and miR-4532) and 2 downregulated (miR-98 and miR-135b) in SPE placentas compared with controls. The present results suggest that SPE is associated with specific alterations in the placental miRNA expression pattern, which differ from alterations detected in PE placentas, and therefore, provide novel targets for further investigation of the molecular mechanisms underlying SPE pathogenesis.

VASHUKOVA E.S. , GLOTOV A.S. , FEDOTOV P.V. , EFIMOVA O.A. , PAKIN V.S. , MOZGOVAYA E.V. , PENDINA A.A. , TIKHONOV A.V. , KOLTSOVA A.S. , BARANOV V.S.
Placental microRNA expression in pregnancies complicated by superimposed pre-eclampsia on chronic hypertension
Molecular Medicine Reports. 2016. V.14. N1. P.22-32. DOI: 10.3892/mmr.2016.5268 WOS OpenAlex

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