Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications

Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications Научная публикация

Журнал

Genes
ISSN: 2073-4425

Вых. Данные

Год: 2022, Том: 13, Номер: 12, Номер статьи : 2255, Страниц : DOI: 10.3390/genes13122255

Авторы

Changalidis Anton ^1,2 , Maksiutenko Evgeniia ^3,1 , Barbitoff Yury ^3,1 , Tkachenko Alexander ¹ , Vashukova Elena ¹ , Pachuliia Olga ¹ , Nasykhova Yulia ¹ , Glotov Andrey ¹

Организации

1	Dpt. of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology, 199034 St. Petersburg, Russia
2	Faculty of Software Engineering and Computer Systems, ITMO University, 197101 St. Petersburg, Russia
3	Dpt. of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia

Complications endangering mother or fetus affect around one in seven pregnant women. Investigation of the genetic susceptibility to such diseases is of high importance for better understanding of the disease biology as well as for prediction of individual risk. In this study, we collected and analyzed GWAS summary statistics from the FinnGen cohort and UK Biobank for 24 pregnancy complications. In FinnGen, we identified 11 loci associated with pregnancy hypertension, excessive vomiting, and gestational diabetes. When UK Biobank and FinnGen data were combined, we discovered six loci reaching genome-wide significance in the meta-analysis. These include rs35954793 in FGF5 (p=6.1×10−9), rs10882398 in PLCE1 (p=8.9×10−9), and rs167479 in RGL3 (p=5.2×10−9) for pregnancy hypertension, rs10830963 in MTNR1B (p=4.5×10−41) and rs36090025 in TCF7L2 (p=3.4×10−15) for gestational diabetes, and rs2963457 in the EBF1 locus (p=6.5×10−9) for preterm birth. In addition to the identified genome-wide associations, we also replicated 14 out of 40 previously reported GWAS markers for pregnancy complications, including four more preeclampsia-related variants. Finally, annotation of the GWAS results identified a causal relationship between gene expression in the cervix and gestational hypertension, as well as both known and previously uncharacterized genetic correlations between pregnancy complications and other traits. These results suggest new prospects for research into the etiology and pathogenesis of pregnancy complications, as well as early risk prediction for these disorders.

Changalidis A. , Maksiutenko E. , Barbitoff Y. , Tkachenko A. , Vashukova E. , Pachuliia O. , Nasykhova Y. , Glotov A.
Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications
Genes. 2022. V.13. N12. 2255 . DOI: 10.3390/genes13122255 OpenAlex

Опубликована online:

30 нояб. 2022 г.

OpenAlex:

W4310387867

БД	Цитирований
OpenAlex	13