Maternal insulin‐like growth factors and insulin‐like growth factor‐binding proteins for macrosomia prediction in diabetic and nondiabetic pregnancy: A prospective study

Maternal insulin‐like growth factors and insulin‐like growth factor‐binding proteins for macrosomia prediction in diabetic and nondiabetic pregnancy: A prospective study Full article

Journal

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
ISSN: 0020-7292

Output data

Year: 2023, Volume: 162, Number: 2, Pages: 605-613 Pages count : 9 DOI: 10.1002/ijgo.14696

Authors

Alekseenkova E.N. ¹ , Babakov V.N. ² , Selkov S.A. ¹ , Di Renzo G.C. ^3,4 , Kogan I.Yu. ^1,5 , Kapustin R.V. ^1,5

Affiliations

1	D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine, St Petersburg, Russia
2	Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA, St Petersburg, Russia
3	Centre for Reproductive and Perinatal Medicine, University of Perugia, Perugia, Italy
4	Wayne State University School of Medicine, Michigan, Detroit, USA
5	Department of Obstetrics, Gynecology and Reproduction, St Petersburg State University, St Petersburg, Russia

Objective Attributable to the insulin-like growth factor (IGF) axis involvement in fetal growth regulation, possible contribution of the maternal IGF axis to antenatal fetal macrosomia diagnosis is a subject of particular interest in diabetic pregnancy. Methods A total of 130 women were prospectively enrolled in a longitudinal single-center cohort study. The four study groups were: type 1 diabetes (n = 40), type 2 diabetes (n = 35), gestational diabetes (n = 40), and control (n = 15). IGF-1 and IGF-2 and insulin-like growth factor-binding protein (IGFBP) 1, 3, 6, and 7 serum levels were analyzed in 11- to 14-week and 30- to 34-week samples with a specific immunoassay. Results In mothers of large-for-gestational-age neonates (90th percentile), higher (median test) first-trimester IGF-1 (P = 0.007) and lower IGFBP-1 (P = 0.035) were observed. The IGF-1/IGFBP-1 ratio was positively associated with neonatal weight (r = 0.434, P < 0.001). Receiver operating characteristic analysis revealed an association between large for gestational age and the first-trimester IGF-1 (area under the curve [AUC] = 0.747, P < 0.001), IGFBP-1 (AUC = 0.334, P = 0.011), and IGF-1/IGFBP-1 ratio (AUC = 0.750, P < 0.001). IGF-1/IGFBP-1 ratio had better performance for prediction of birth weight over 4000 g (AUC = 0.822, P < 0.001). Conclusion The authors detected different first-trimester IGF-1 and IGF-1/IGFBP-1 thresholds applicable for either supposition or rejection of macrosomia diagnosis. Further investigation is needed to determine how the maternal IGF axis can contribute to fetal macrosomia prediction.

Alekseenkova E.N. , Babakov V.N. , Selkov S.A. , Di Renzo G.C. , Kogan I.Y. , Kapustin R.V.
Maternal insulin‐like growth factors and insulin‐like growth factor‐binding proteins for macrosomia prediction in diabetic and nondiabetic pregnancy: A prospective study
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS. 2023. V.162. N2. P.605-613. DOI: 10.1002/ijgo.14696 WOS Scopus РИНЦ OpenAlex

Published online:

Jan 23, 2023

Web of science:	WOS:000931157700001
Scopus:	eid_2-s2.0-85147999542
Elibrary:	50234800
OpenAlex:	W4318391225

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