Impact of Antithyroperoxidase Antibodies (Anti-TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles

Impact of Antithyroperoxidase Antibodies (Anti-TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles Full article

Journal

International Journal of Molecular Sciences
ISSN: 1661-6596 , E-ISSN: 1422-0067

Output data

Year: 2023, Volume: 24, Number: 5, Article number : 4705, Pages count : DOI: 10.3390/ijms24054705

Authors

Safarian Galina Kh. ¹ , Niauri Dariko A. ^1,2 , Kogan Igor Y. ^1,2 , Bespalova Olesya N. ^1,2 , Dzhemlikhanova Lyailya Kh. ^1,2 , Lesik Elena A. ¹ , Komarova Evgeniya M. ¹ , Krikheli Inna O. ¹ , Obedkova Ksenia V. ¹ , Tkachenko Nataliya N. ¹ , Milyutina Yulia P. ¹ , Gzgzyan Aleksandr M. ^1,2 , Shoenfeld Yehuda ³

Affiliations

1	D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. Petersburg 199034, Russia
2	Medical Faculty, Saint Petersburg State University, St. Petersburg 199106, Russia
3	Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5265601, Israel

Autoimmune thyroid disease (AITD) is one of the most common endocrinopathies and is more prevalent in women. It becomes evident that the circulating antithyroid antibodies that often follow AITD have effects on many tissues, including ovaries, and therefore that this common morbidity might have an impact on female fertility, the investigation of which is the aim of the present research. Ovarian reserve, ovarian response to stimulation and early embryo development in infertile patients with thyroid autoimmunity were assessed in 45 women with thyroid autoimmunity and 45 age-matched control patients undergoing infertility treatment. It was demonstrated that the presence of anti-thyroid peroxidase antibodies is associated with lower serum anti-Müllerian hormone levels and antral follicle count. Further investigation revealed the higher prevalence of sub-optimal response to ovarian stimulation in TAI-positive women, lower fertilization rate and lower number of high-quality embryos in this group of patients. The cut-off value for follicular fluid anti-thyroid peroxidase antibody affecting the above-mentioned parameters was determined to be 105.0 IU/mL, highlighting the necessity of closer monitoring in couples seeking infertility treatment with ART.

Safarian G.K. , Niauri D.A. , Kogan I.Y. , Bespalova O.N. , Dzhemlikhanova L.K. , Lesik E.A. , Komarova E.M. , Krikheli I.O. , Obedkova K.V. , Tkachenko N.N. , Milyutina Y.P. , Gzgzyan A.M. , Shoenfeld Y.
Impact of Antithyroperoxidase Antibodies (Anti-TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles
International Journal of Molecular Sciences. 2023. V.24. N5. 4705 . DOI: 10.3390/ijms24054705 WOS Scopus РИНЦ OpenAlex

Published online:

Feb 28, 2023

Web of science:	WOS:000948269800001
Scopus:	2-s2.0-85149898491
Elibrary:	50380062
OpenAlex:	W4322743139

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Web of science	4
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