Plasma miRNA Profile in High Risk of Preterm Birth during Early and Mid-Pregnancy

Plasma miRNA Profile in High Risk of Preterm Birth during Early and Mid-Pregnancy Full article

Journal

Genes
ISSN: 2073-4425

Output data

Year: 2022, Volume: 13, Number: 11, Article number : 2018, Pages count : DOI: 10.3390/genes13112018

Authors

Illarionov Roman A ^1,2 , Pachuliia Olga V ¹ , Vashukova Elena S ¹ , Tkachenko Alexander A ^1,3 , Maltseva Anastasia R ¹ , Postnikova Tatyana B ¹ , Nasykhova Yulia A ¹ , Olesya N Bespalova ¹ , Glotov Andrey S ¹

Affiliations

1	Department of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, Russia
2	Resource Center “Biobank”, St. Petersburg State University, St. Petersburg 199034, Russia
3	Institute of Applied Computer Sciences, ITMO University, St. Petersburg 197101, Russia

In recent years evidence has been accumulated showing that miRNAs can act as potential biomarkers or targets for therapy of preterm birth, one of the most important problems in modern obstetrics. We have performed a prospective study of the miRNA profile in the plasma during the first and second trimesters in pregnant women with high risk of preterm birth (n = 13 cases and n = 11 controls). For the study group plasma blood samples at 9–13 weeks before diagnosis and at 22–24 weeks after start of therapy were selected. Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated—hsa-miR-122-5p, hsa-miR-34a-5p, hsa-miR-34c-5p; 12 downregulated—hsa-miR-487b-3p, hsa-miR-493-3p, hsa-miR-432-5p, hsa-miR-323b-3p, hsa-miR-369-3p, hsa-miR-134-5p, hsa-miR-431-5p, hsa-miR-485-5p, hsa-miR-382-5p, hsa-miR-369-5p, hsa-miR-485-3p, hsa-miR-127-3p) (log2(FC) ≥ 1.5; FDR ≤ 0.05) during the first trimester compared with the control (non-high-risk of preterm birth pregnant women). All downregulated miRNAs in the first trimester from the placenta-specific C14MC cluster. During the second trimester no differentially expressed miRNAs were found. Our results suggest that the miRNA profile in plasma during early pregnancy may predict a high risk of preterm birth, which is important in preventing gestational problems as early as possible.

Illarionov R.A. , Pachuliia O.V. , Vashukova E.S. , Tkachenko A.A. , Maltseva A.R. , Postnikova T.B. , Nasykhova Y.A. , Olesya N Bespalova , Glotov A.S.
Plasma miRNA Profile in High Risk of Preterm Birth during Early and Mid-Pregnancy
Genes. 2022. V.13. N11. 2018 . DOI: 10.3390/genes13112018 WOS Scopus РИНЦ OpenAlex

Published online:

Nov 3, 2022

Web of science:	WOS:000882645200001
Scopus:	2-s2.0-85141554913
Elibrary:	49945638
OpenAlex:	W4308955840

DB	Citing
OpenAlex	19
Web of science	12
Scopus	10