Differences in human papillomavirus type distribution in high‐grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe

Differences in human papillomavirus type distribution in high‐grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe Научная публикация

Журнал

International Journal of Cancer
ISSN: 1097-0215 , E-ISSN: 0020-7136

Вых. Данные

Год: 2012, Том: 132, Номер: 4, Страницы: 854-867 Страниц : 14 DOI: 10.1002/ijc.27713

Авторы

Tjalma Wiebren A. ¹ , Fiander Alison ² , Reich Olaf ³ , Powell Ned ² , Nowakowski Andrzej M. ⁴ , Kirschner Benny ⁵ , Koiss Robert ⁶ , O'Leary John ⁷ , Joura Elmar A. ⁸ , Rosenlund Mats ⁹ , Colau Brigitte ¹⁰ , Schledermann Doris ¹¹ , Kukk Kersti ¹² , Damaskou Vasileia ¹³ , Repanti Maria ¹³ , Vladareanu Radu ¹⁴ , Kolomiets Larisa ¹⁵ , Savicheva Alevtina ¹⁶ , Shipitsyna Elena ¹⁶ , Ordi Jaume ¹⁷ , Molijn Anco ¹⁸ , Quint Wim ¹⁸ , Raillard Alice ¹⁹ , Rosillon Dominique ⁹ , De Souza Sabrina Collas ¹⁹ , Jenkins David ²⁰ , Holl Katsiaryna ⁹

Организации

1	Department of Gynecology and Gynecologic Oncology, University Hospital Antwerpen, University of Antwerp, Antwerpen, Belgium
2	Section of Obstetrics and Gynaecology, Cardiff University School of Medicine, Wales, United Kingdom
3	Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria
4	First Department of Oncologic Gynaecology and Gynaecology, Medical University of Lublin, Lublin, Poland
5	Department of Pathology, Hvidovre University Hospital, Hvidovre, Denmark
6	Department of Obstetrics and Gynecologic Oncology, St. Stephan Hospital, Budapest, Hungary
7	CERVIVA Research Consortium, Health Research Board Ireland, Department of Pathology, The Coombe Women and Infants University Hospital and Trinity College, Dublin, Ireland
8	Comprehensive Cancer Center, Department of Gynaecology and Obstetrics, Medical University of Vienna, Vienna, Austria
9	Epidemiology Department, GlaxoSmithKline Biologicals, Wavre, Belgium
10	R&D Department, GlaxoSmithKline Biologicals, Rixensart, Belgium
11	Department of Pathology, Odense University Hospital, Odense, Denmark
12	Department of Gynecological Oncology, North Estonian Medical Centre Foundation, Tallinn, Estonia
13	Department of Histopathology, ‘Agios Andreas’, Patras General Hospital, Patras, Greece
14	Department of Obstetrics and Gynecology, ‘Elias’ University Emergency Hospital, Bucharest, Romania
15	Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk, Russia
16	Laboratory of Microbiology, Do Ott Research Institute of Obstetrics and Gynaecology, St. Petersburg, Russia
17	Centre de Recerca en Salut Internacional de Barcelona (CRESIB) Hospital Clı´nic, Department of Pathology, University of Barcelona, Barcelona, Spain
18	DDL Diagnostic Laboratory, Rijswijk, The Netherlands
19	4Clinics, Paris, France
20	Department of Pathology, Nottingham University, Nottingham, United Kingdom

Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopathology review and standardised HPV-DNA typing were applied to formalin-fixed paraffin-embedded cervical specimens dated 2001-2008. The pooled prevalence of individual HPV types was estimated using meta-analytic methods. A total of 3,103 women were diagnosed with HG-CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV-positive, respectively. The most common HPV types in women with HG-CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times higher in ICC than in HG-CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31/33/'other' (23/20/17 years), and for HPV45 (1 year) than HPV16/31/33/'other' (15/23/20/17 years). In Europe, HPV16 predominates in both HG-CIN and ICC, whereas HPV18/45 are associated with a low median age of ICC. HPV18/45 are more frequent in ICC than HG-CIN and associated with a high median age of HG-CIN, with a narrow age interval between HG-CIN and ICC detection. These findings support the need for primary prevention of HPV16/18/45-related cervical lesions.

Tjalma W.A. , Fiander A. , Reich O. , Powell N. , Nowakowski A.M. , Kirschner B. , Koiss R. , O'Leary J. , Joura E.A. , Rosenlund M. , Colau B. , Schledermann D. , Kukk K. , Damaskou V. , Repanti M. , Vladareanu R. , Kolomiets L. , Savicheva A. , Shipitsyna E. , Ordi J. , Molijn A. , Quint W. , Raillard A. , Rosillon D. , De Souza S.C. , Jenkins D. , Holl K.
Differences in human papillomavirus type distribution in high‐grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe
International Journal of Cancer. 2012. V.132. N4. P.854-867. DOI: 10.1002/ijc.27713 WOS Scopus РИНЦ OpenAlex

Опубликована online:

3 июл. 2012 г.

Web of science:	WOS:000314069400012
Scopus:	eid_2-s2.0-84871378209
РИНЦ:	20488399
OpenAlex:	W2045600910

БД	Цитирований
OpenAlex	210
Web of science	165