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The Evolution of Ideas on the Biological Role of 5-methylcytosine Oxidative Derivatives in the Mammalian Genome Научная публикация

Журнал Russian Journal of Genetics: Applied Research
ISSN: 2079-0597 , E-ISSN: 2079-0600
Вых. Данные Год: 2018, Том: 8, Номер: 1, Страницы: 11-21 Страниц : 11 DOI: 10.1134/s2079059718010069
Авторы Efimova O.A. 1 , Pendina A.A. 1 , Tikhonov A.V. 1 , Baranov V.S. 1
Организации
1 Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, 199034, Russia

Реферат: ⎯In this review, we summarize the data on 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine—cytosine modifications which are produced by TET-mediated oxidation of 5-methylcytosine in DNA. We show the biochemistry of modified cytosine, as well as methods for its global and location analysis. We also highlight the milestones in the evolution of ideas on the biological role of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine in the mammalian genome from their discovery in 2009 to the present time.
Библиографическая ссылка: Efimova O.A. , Pendina A.A. , Tikhonov A.V. , Baranov V.S.
The Evolution of Ideas on the Biological Role of 5-methylcytosine Oxidative Derivatives in the Mammalian Genome
Russian Journal of Genetics: Applied Research. 2018. V.8. N1. P.11-21. DOI: 10.1134/s2079059718010069 OpenAlex
Идентификаторы БД:
OpenAlex: W2790479974
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