The Evolution of Ideas on the Biological Role of 5-methylcytosine Oxidative Derivatives in the Mammalian Genome

The Evolution of Ideas on the Biological Role of 5-methylcytosine Oxidative Derivatives in the Mammalian Genome Full article

Journal

Russian Journal of Genetics: Applied Research
ISSN: 2079-0597 , E-ISSN: 2079-0600

Output data

Year: 2018, Volume: 8, Number: 1, Pages: 11-21 Pages count : 11 DOI: 10.1134/s2079059718010069

Authors

Efimova O.A. ¹ , Pendina A.A. ¹ , Tikhonov A.V. ¹ , Baranov V.S. ¹

Affiliations

1	Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, 199034, Russia

⎯In this review, we summarize the data on 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine—cytosine modifications which are produced by TET-mediated oxidation of 5-methylcytosine in DNA. We show the biochemistry of modified cytosine, as well as methods for its global and location analysis. We also highlight the milestones in the evolution of ideas on the biological role of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine in the mammalian genome from their discovery in 2009 to the present time.

Efimova O.A. , Pendina A.A. , Tikhonov A.V. , Baranov V.S.
The Evolution of Ideas on the Biological Role of 5-methylcytosine Oxidative Derivatives in the Mammalian Genome
Russian Journal of Genetics: Applied Research. 2018. V.8. N1. P.11-21. DOI: 10.1134/s2079059718010069 OpenAlex

OpenAlex:

W2790479974

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