Oxidized form of 5-methylcytosine—5-hydroxymethylcytosine: a new insight into the biological significance in the mammalian genome

Oxidized form of 5-methylcytosine—5-hydroxymethylcytosine: a new insight into the biological significance in the mammalian genome Full article

Journal

Russian Journal of Genetics: Applied Research
ISSN: 2079-0597 , E-ISSN: 2079-0600

Output data

Year: 2015, Volume: 5, Number: 2, Pages: 75-81 Pages count : 7 DOI: 10.1134/s2079059715020033

Authors

Efimova O.A. ¹ , Pendina A.A. ¹ , Tikhonov A.V. ¹ , Kuznetzova T.V. ¹ , Baranov V.S. ¹

Affiliations

1	D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia

In this review, we summarize data on 5hydroxymethylcytosine—a modification of cytosine with a recently discovered epigenetic effect. We discuss the biochemical mechanisms of 5hydroxymethylcytosine generation and further modification in the mammalian genome, analyze the role of 5hydroxymethylcy tosine in the epigenetic reprogramming during mammalian gametogenesis and early embryogenesis as well as in the regulation of gene expression. We also show recent data on the diseases and the adverse environmental factors, linked to the DNA hydroxymethylation disruptions.

Efimova O.A. , Pendina A.A. , Tikhonov A.V. , Kuznetzova T.V. , Baranov V.S.
Oxidized form of 5-methylcytosine—5-hydroxymethylcytosine: a new insight into the biological significance in the mammalian genome
Russian Journal of Genetics: Applied Research. 2015. V.5. N2. P.75-81. DOI: 10.1134/s2079059715020033 OpenAlex

OpenAlex:

W2040248127

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